Ellis, University of Louisville, United States of America

We found many mitochondrial genes to be down regulated upon H 2S treatment and that H 2S can reduce mitochondrial oxygen consumption.Д¬itation: Jia X, He W, Murchie AIH, Chen D (2011) The Global Transcriptional Response of Fission Yeast to Hydrogen Sulfide. We identified that the target genes of the MAPK pathway respond to H 2S we also identified that a number of transporters respond to H 2S, these include sugar/carbohydrate transporters, ion transporters, and amino acid transporters. Our analysis showed that there was a significant overlap between the genes affected by H 2S and the stress response. Through the functional classification of genes whose expression profile changed in response to H 2S, we found that H 2S mainly influences genes that encode putative or known stress proteins, membrane transporters, cell cycle/meiotic proteins, transcription factors and respiration protein in the mitochondrion. We initially measured the genome-wide transcriptional response of fission yeast to H 2S. In this paper, we have used fission yeast as a model organism to study the global gene expression profile in response to H 2S by microarray.

Fission vs fusion venn diagram